p53 negatively regulates Aurora A via both transcriptional and posttranslational regulation

p53 plays an important role in mitotic checkpoint, but what its role is remains enigmatic. Aurora A is a Ser/Thr kinase involved in correcting progression of mitosis. Here, we show that p53 is a negative regulator for Aurora A. We found that p53 deficiency leads to Aurora A elevation. Ectopic expres...

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Main Authors: Wu, Chun-Chi, Yang, Tsung-Ying, Yu, Chang-Tze Ricky, Phan, Liem, Ivan, Cristina, Sood, Anil K., Hsu, Shih-Lan, Lee, Mong-Hong
Formáid: Artigo
Teanga:Inglês
Foilsithe: Landes Bioscience 2012
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Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3466554/
https://ncbi.nlm.nih.gov/pubmed/22894933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.21732
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