Učitavanje...
p53 negatively regulates Aurora A via both transcriptional and posttranslational regulation
p53 plays an important role in mitotic checkpoint, but what its role is remains enigmatic. Aurora A is a Ser/Thr kinase involved in correcting progression of mitosis. Here, we show that p53 is a negative regulator for Aurora A. We found that p53 deficiency leads to Aurora A elevation. Ectopic expres...
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| Glavni autori: | , , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Landes Bioscience
2012
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3466554/ https://ncbi.nlm.nih.gov/pubmed/22894933 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.21732 |
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