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Emerging roles of PKM2 in cell metabolism and cancer progression
Increased conversion of glucose to lactate is a key feature of many cancer cells that promotes rapid growth. Pyruvate kinase M2 (PKM2) expression is increased and facilitates lactate production in cancer cells. Modulation of PKM2 catalytic activity also regulates synthesis of DNA and lipids required...
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| Main Authors: | , |
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| Formáid: | Artigo |
| Teanga: | Inglês |
| Foilsithe: |
2012
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| Ábhair: | |
| Rochtain Ar Líne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3466350/ https://ncbi.nlm.nih.gov/pubmed/22824010 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tem.2012.06.010 |
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