Flexible trial design in practice - stopping arms for lack-of-benefit and adding research arms mid-trial in STAMPEDE: a multi-arm multi-stage randomized controlled trial

BACKGROUND: Systemic Therapy for Advanced or Metastatic Prostate cancer: Evaluation of Drug Efficacy (STAMPEDE) is a randomized controlled trial that follows a novel multi-arm, multi-stage (MAMS) design. We describe methodological and practical issues arising with (1) stopping recruitment to researc...

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Detalhes bibliográficos
Main Authors: Sydes, Matthew R, Parmar, Mahesh KB, Mason, Malcolm D, Clarke, Noel W, Amos, Claire, Anderson, John, de Bono, Johann, Dearnaley, David P, Dwyer, John, Green, Charlene, Jovic, Gordana, Ritchie, Alastair WS, Russell, J Martin, Sanders, Karen, Thalmann, George, James, Nicholas D
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2012
Assuntos:
Methodology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3466132/
https://ncbi.nlm.nih.gov/pubmed/22978443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1745-6215-13-168
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