Flexible trial design in practice - stopping arms for lack-of-benefit and adding research arms mid-trial in STAMPEDE: a multi-arm multi-stage randomized controlled trial

<p>Abstract</p> <p>Background</p> <p>Systemic Therapy for Advanced or Metastatic Prostate cancer: Evaluation of Drug Efficacy (STAMPEDE) is a randomized controlled trial that follows a novel multi-arm, multi-stage (MAMS) design. We describe methodological and practical...

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Main Authors: Sydes Matthew R, Parmar Mahesh KB, Mason Malcolm D, Clarke Noel W, Amos Claire, Anderson John, de Bono Johann, Dearnaley David P, Dwyer John, Green Charlene, Jovic Gordana, Ritchie Alastair WS, Russell J, Sanders Karen, Thalmann George, James Nicholas D
格式: Artigo
語言:Inglês
出版: BMC 2012-09-01
叢編:Trials
主題:
Novel design
Multi-arm multi-stage design
Implementation
Prostate cancer
Methodology
Randomized controlled trial
在線閱讀:http://www.trialsjournal.com/content/13/1/168
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