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Flexible trial design in practice - stopping arms for lack-of-benefit and adding research arms mid-trial in STAMPEDE: a multi-arm multi-stage randomized controlled trial
<p>Abstract</p> <p>Background</p> <p>Systemic Therapy for Advanced or Metastatic Prostate cancer: Evaluation of Drug Efficacy (STAMPEDE) is a randomized controlled trial that follows a novel multi-arm, multi-stage (MAMS) design. We describe methodological and practical...
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| Main Authors: | , , , , , , , , , , , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
BMC
2012-09-01
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| 叢編: | Trials |
| 主題: | |
| 在線閱讀: | http://www.trialsjournal.com/content/13/1/168 |
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