Intestinal DGAT1 deficiency reduces postprandial triglyceride and retinyl ester excursions by inhibiting chylomicron secretion and delaying gastric emptying

Acyl CoA:diacylglycerol acyltransferase (DGAT) 1 catalyzes the final step of triglyceride (TG) synthesis. We show that acute administration of a DGAT1 inhibitor (DGAT1i) by oral gavage or genetic deletion of intestinal Dgat1 (intestine-Dgat1(−/−)) markedly reduced postprandial plasma TG and retinyl...

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Main Authors: Ables, Gene P., Yang, Kryscilla Jian Zhang, Vogel, Silke, Hernandez-Ono, Antonio, Yu, Shuiqing, Yuen, Jason J., Birtles, Susan, Buckett, Linda K., Turnbull, Andrew V., Goldberg, Ira J., Blaner, William S., Huang, Li-Shin, Ginsberg, Henry N.
格式: Artigo
語言:Inglês
出版: The American Society for Biochemistry and Molecular Biology 2012
主題:
Research Articles
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3466005/
https://ncbi.nlm.nih.gov/pubmed/22911105
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M029041
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