Intestinally Targeted Diacylglycerol Acyltransferase 1 (DGAT1) Inhibitors Robustly Suppress Postprandial Triglycerides

[Image: see text] High DGAT1 expression levels in the small intestine highlight the critical role this enzyme plays in nutrient absorption. Identification of inhibitors which predominantly inhibit DGAT1 in the gut is an attractive drug discovery strategy with anticipated benefits of reduced systemic...

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Detalhes bibliográficos
Main Authors: Serrano-Wu, Michael H., Coppola, Gary M., Gong, Yongjin, Neubert, Alan D., Chatelain, Ricardo, Clairmont, Kevin B., Commerford, Renee, Cosker, Theresa, Daniels, Thomas, Hou, Ying, Jain, Monish, Juedes, Marlene, Li, Lisha, Mullarkey, Tara, Rocheford, Erik, Sung, Moo Je, Tyler, Andrew, Yang, Qing, Yoon, Taeyoung, Hubbard, Brian K.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2012
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4025815/
https://ncbi.nlm.nih.gov/pubmed/24900485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml3000512
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