Intestinally Targeted Diacylglycerol Acyltransferase 1 (DGAT1) Inhibitors Robustly Suppress Postprandial Triglycerides

[Image: see text] High DGAT1 expression levels in the small intestine highlight the critical role this enzyme plays in nutrient absorption. Identification of inhibitors which predominantly inhibit DGAT1 in the gut is an attractive drug discovery strategy with anticipated benefits of reduced systemic...

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Hlavní autoři: Serrano-Wu, Michael H., Coppola, Gary M., Gong, Yongjin, Neubert, Alan D., Chatelain, Ricardo, Clairmont, Kevin B., Commerford, Renee, Cosker, Theresa, Daniels, Thomas, Hou, Ying, Jain, Monish, Juedes, Marlene, Li, Lisha, Mullarkey, Tara, Rocheford, Erik, Sung, Moo Je, Tyler, Andrew, Yang, Qing, Yoon, Taeyoung, Hubbard, Brian K.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Chemical Society 2012
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4025815/
https://ncbi.nlm.nih.gov/pubmed/24900485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml3000512
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