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Large-scale mapping of branchpoints in human pre-mRNA transcripts in vivo

We present the first large-scale identification of lariats—the transient branched introns that are released as a byproduct of pre-mRNA splicing. The locations of the branchpoints in these introns provide insight into the early steps of splicing. From this data set, we have developed a comprehensive...

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Hlavní autoři: Taggart, Allison J, DeSimone, Alec M, Shih, Janice S, Filloux, Madeleine E, Fairbrother, William G
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3465671/
https://ncbi.nlm.nih.gov/pubmed/22705790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2327
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