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Using positional distribution to identify splicing elements and predict pre-mRNA processing defects in human genes

We present an intuitive strategy for predicting the effect of sequence variation on splicing. In contrast to transcriptional elements, splicing elements appear to be strongly position dependent. We demonstrated that exonic binding of the normally intronic splicing factor, U2AF65, inhibits splicing....

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Detalhes bibliográficos
Main Authors: Lim, Kian Huat, Ferraris, Luciana, Filloux, Madeleine E., Raphael, Benjamin J., Fairbrother, William G.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3131313/
https://ncbi.nlm.nih.gov/pubmed/21685335
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1101135108
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