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Variability of DNA methylation patterns during serial passage of human diploid fibroblasts

We have examined DNA methylation in diploid human fibroblasts, early and late in their replicative life-span. The extent of methylation of -C-C-G-G- was measured by comparison of fragment sizes after digestion with methylation-specific restriction enzyme Hpa II or Msp I, or both. Methylation of -C-C...

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Foilsithe in:Proc Natl Acad Sci U S A
Príomhchruthaitheoirí: Reis, Robert J. Shmookler, Goldstein, Samuel
Formáid: Artigo
Teanga:Inglês
Foilsithe / Cruthaithe: National Academy of Sciences 1982
Ábhair:
Rochtain ar líne:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC346553/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6287455/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.79.13.3949
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