Variability of DNA methylation patterns during serial passage of human diploid fibroblasts
We have examined DNA methylation in diploid human fibroblasts, early and late in their replicative life-span. The extent of methylation of -C-C-G-G- was measured by comparison of fragment sizes after digestion with methylation-specific restriction enzyme Hpa II or Msp I, or both. Methylation of -C-C...
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| 發表在: | Proc Natl Acad Sci U S A |
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| Principais autores: | , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
National Academy of Sciences
1982
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC346553/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6287455/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.79.13.3949 |
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