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Variability of DNA methylation patterns during serial passage of human diploid fibroblasts

We have examined DNA methylation in diploid human fibroblasts, early and late in their replicative life-span. The extent of methylation of -C-C-G-G- was measured by comparison of fragment sizes after digestion with methylation-specific restriction enzyme Hpa II or Msp I, or both. Methylation of -C-C...

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Dettagli Bibliografici
Autori principali: Reis, Robert J. Shmookler, Goldstein, Samuel
Natura: Artigo
Lingua:Inglês
Pubblicazione: 1982
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC346553/
https://ncbi.nlm.nih.gov/pubmed/6287455
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