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Variability of DNA methylation patterns during serial passage of human diploid fibroblasts
We have examined DNA methylation in diploid human fibroblasts, early and late in their replicative life-span. The extent of methylation of -C-C-G-G- was measured by comparison of fragment sizes after digestion with methylation-specific restriction enzyme Hpa II or Msp I, or both. Methylation of -C-C...
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| Main Authors: | , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
1982
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC346553/ https://ncbi.nlm.nih.gov/pubmed/6287455 |
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