Synthesis and Biological Evaluation of Two Agents for Imaging Estrogen Receptor β by Positron Emission Tomography: Challenges in PET Imaging of a Low Abundance Target

INTRODUCTION: Independent measurement of the levels of both the estrogen receptors, ERα and ERβ, in breast cancer could improve prediction of benefit from endocrine therapies. While ERα levels can be measured by positron emission tomography (PET) using 16α-[(18)F]fluoroestradiol (FES), no effective...

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Main Authors: HakLee, Jae, Peters, Olaf, Lehmann, Lutz, Dence, Carmen S., Sharp, Terry L., Carlson, Kathryn E., Zhou, Dong, Jeyakumar, M., Welch, Michael J., Katzenellenbogen, John A.
Format: Artigo
Sprog:Inglês
Udgivet: 2012
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3465515/
https://ncbi.nlm.nih.gov/pubmed/22749433
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nucmedbio.2012.05.011
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