Poly(ADP-ribosyl)ation Acts in the DNA Demethylation of Mouse Primordial Germ Cells Also with DNA Damage-Independent Roles

Poly(ADP-ribosyl)ation regulates chromatin structure and transcription driving epigenetic events. In particular, Parp1 is able to directly influence DNA methylation patterns controlling transcription and activity of Dnmt1. Here, we show that ADP-ribose polymer levels and Parp1 expression are noticea...

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Detalhes bibliográficos
Main Authors: Ciccarone, Fabio, Klinger, Francesca Gioia, Catizone, Angela, Calabrese, Roberta, Zampieri, Michele, Bacalini, Maria Giulia, De Felici, Massimo, Caiafa, Paola
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3465317/
https://ncbi.nlm.nih.gov/pubmed/23071665
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0046927
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