Poly(ADP-ribosyl)ation Acts in the DNA Demethylation of Mouse Primordial Germ Cells Also with DNA Damage-Independent Roles

Poly(ADP-ribosyl)ation regulates chromatin structure and transcription driving epigenetic events. In particular, Parp1 is able to directly influence DNA methylation patterns controlling transcription and activity of Dnmt1. Here, we show that ADP-ribose polymer levels and Parp1 expression are noticea...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Ciccarone, Fabio, Klinger, Francesca Gioia, Catizone, Angela, Calabrese, Roberta, Zampieri, Michele, Bacalini, Maria Giulia, De Felici, Massimo, Caiafa, Paola
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Public Library of Science 2012
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3465317/
https://ncbi.nlm.nih.gov/pubmed/23071665
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0046927
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