Poly(ADP-ribosyl)ation Acts in the DNA Demethylation of Mouse Primordial Germ Cells Also with DNA Damage-Independent Roles

Poly(ADP-ribosyl)ation regulates chromatin structure and transcription driving epigenetic events. In particular, Parp1 is able to directly influence DNA methylation patterns controlling transcription and activity of Dnmt1. Here, we show that ADP-ribose polymer levels and Parp1 expression are noticea...

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Библиографические подробности
Главные авторы: Ciccarone, Fabio, Klinger, Francesca Gioia, Catizone, Angela, Calabrese, Roberta, Zampieri, Michele, Bacalini, Maria Giulia, De Felici, Massimo, Caiafa, Paola
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2012
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Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3465317/
https://ncbi.nlm.nih.gov/pubmed/23071665
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0046927
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