Production and characterization of monoclonal antibodies to rat liver microsomal 3-hydroxy-3-methylglutaryl-coenzyme A reductase.

Rat liver microsomal 3-hydroxy-3-methylglutaryl-CoA reductase [HMG-CoA reductase; mevalonate:NADP+ oxidoreductase (CoA-acylating), EC 1.1.1.34], the key regulatory enzyme in cholesterol biosynthesis, has been purified to apparent homogeneity. Purified HMG-CoA reductase yields a single diffuse band w...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Clark, R E, Martin, G G, Barton, M C, Shapiro, D J
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1982
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC346501/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6954516/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.79.12.3734
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