Incorporation of the B18R Gene of Vaccinia Virus Into an Oncolytic Herpes Simplex Virus Improves Antitumor Activity

Interferon (IFN) antiviral defense mechanism plays a critical role in controlling virus infection. It thus represents a formidable hurdle for virotherapy. Despite the reported ability of herpes simplex virus (HSV) to counteract this defense, the duration and extent of HSV infection in vivo is still...

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Autori principali: Fu, Xinping, Rivera, Armando, Tao, Lihua, Zhang, Xiaoliu
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2012
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3464635/
https://ncbi.nlm.nih.gov/pubmed/22692498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2012.113
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