The Apo-structure of the Low Molecular Weight Protein-tyrosine Phosphatase A (MptpA) from Mycobacterium tuberculosis Allows for Better Target-specific Drug Development

Protein-tyrosine phosphatases (PTPs) and protein-tyrosine kinases co-regulate cellular processes. In pathogenic bacteria, they are frequently exploited to act as key virulence factors for human diseases. Mycobacterium tuberculosis, the causative organism of tuberculosis, secretes a low molecular wei...

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Detalhes bibliográficos
Main Authors: Stehle, Tanja, Sreeramulu, Sridhar, Löhr, Frank, Richter, Christian, Saxena, Krishna, Jonker, Hendrik R. A., Schwalbe, Harald
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3464563/
https://ncbi.nlm.nih.gov/pubmed/22888002
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.399261
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