The M-T Hook Structure Is Critical for Design of HIV-1 Fusion Inhibitors

CP621-652 is a potent HIV-1 fusion inhibitor peptide derived from the C-terminal heptad repeat of gp41. We recently identified that its N-terminal residues Met-626 and Thr-627 adopt a unique hook-like structure (termed M-T hook) thus stabilizing the interaction of the inhibitor with the deep pocket...

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Autori principali: Chong, Huihui, Yao, Xue, Sun, Jianping, Qiu, Zonglin, Zhang, Meng, Waltersperger, Sandro, Wang, Meitian, Cui, Sheng, He, Yuxian
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2012
Soggetti:
Microbiology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3464562/
https://ncbi.nlm.nih.gov/pubmed/22879603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.390393
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