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The M-T Hook Structure Is Critical for Design of HIV-1 Fusion Inhibitors
CP621-652 is a potent HIV-1 fusion inhibitor peptide derived from the C-terminal heptad repeat of gp41. We recently identified that its N-terminal residues Met-626 and Thr-627 adopt a unique hook-like structure (termed M-T hook) thus stabilizing the interaction of the inhibitor with the deep pocket...
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| Hauptverfasser: | , , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society for Biochemistry and Molecular Biology
2012
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3464562/ https://ncbi.nlm.nih.gov/pubmed/22879603 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.390393 |
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