Structural Basis of Potent and Broad HIV-1 Fusion Inhibitor CP32M

CP32M is a newly designed peptide fusion inhibitor possessing potent anti-HIV activity, especially against T20-resistant HIV-1 strains. In this study, we show that CP32M can efficiently inhibit a large panel of diverse HIV-1 variants, including subtype B′, CRF07_BC, and CRF01_AE recombinants and nat...

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Detalhes bibliográficos
Main Authors: Yao, Xue, Chong, Huihui, Zhang, Chao, Qiu, Zonglin, Qin, Bo, Han, Ruiyun, Waltersperger, Sandro, Wang, Meitian, He, Yuxian, Cui, Sheng
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Microbiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3411002/
https://ncbi.nlm.nih.gov/pubmed/22679024
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.381079
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