A Novel Approach to Recovery of Function of Mutant Proteins by Slowing Down Translation

Protein homeostasis depends on a balance of translation, folding, and degradation. Here, we demonstrate that mild inhibition of translation results in a dramatic and disproportional reduction in production of misfolded polypeptides in mammalian cells, suggesting an improved folding of newly synthesi...

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Main Authors: Meriin, Anatoli B., Mense, Martin, Colbert, Jeff D., Liang, Feng, Bihler, Hermann, Zaarur, Nava, Rock, Kenneth L., Sherman, Michael Y.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2012
Teme:
Protein Synthesis and Degradation
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3464534/
https://ncbi.nlm.nih.gov/pubmed/22902621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.397307
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