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Association of translation factor eEF1A with defective ribosomal products generates a signal for aggresome formation
Aggresome formation is initiated upon proteasome failure, and facilitates autophagic clearance of protein aggregates to protect cells from proteotoxicity. Here we demonstrate that proteasome inhibition generates a signaling event to trigger aggresome formation. In aggresome signaling, the cell sense...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Company of Biologists
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3403235/ https://ncbi.nlm.nih.gov/pubmed/22357952 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.098954 |
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