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A Novel Approach to Recovery of Function of Mutant Proteins by Slowing Down Translation
Protein homeostasis depends on a balance of translation, folding, and degradation. Here, we demonstrate that mild inhibition of translation results in a dramatic and disproportional reduction in production of misfolded polypeptides in mammalian cells, suggesting an improved folding of newly synthesi...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3464534/ https://ncbi.nlm.nih.gov/pubmed/22902621 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.397307 |
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