Activation of Transcription Factor MEF2D by Bis(3)-cognitin Protects Dopaminergic Neurons and Ameliorates Parkinsonian Motor Defects

Parkinson disease (PD) is characterized by the selective demise of dopaminergic (DA) neurons in the substantial nigra pars compacta. Dysregulation of transcriptional factor myocyte enhancer factor 2D (MEF2D) has been implicated in the pathogenic process in in vivo and in vitro models of PD. Here, we...

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Detalhes bibliográficos
Main Authors: Yao, Lu, Li, Wenming, She, Hua, Dou, Juan, Jia, Leili, He, Yingli, Yang, Qian, Zhu, Jinqiu, Cápiro, Natalie L., Walker, Douglas I., Pennell, Kurt D., Pang, Yuanping, Liu, Yong, Han, Yifan, Mao, Zixu
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Neurobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3464532/
https://ncbi.nlm.nih.gov/pubmed/22891246
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.367540
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