Site-specific O-Glucosylation of the Epidermal Growth Factor-like (EGF) Repeats of Notch: EFFICIENCY OF GLYCOSYLATION IS AFFECTED BY PROPER FOLDING AND AMINO ACID SEQUENCE OF INDIVIDUAL EGF REPEATS

O-Glucosylation of epidermal growth factor-like (EGF) repeats in the extracellular domain of Notch is essential for Notch function. O-Glucose can be elongated by xylose to the trisaccharide, Xylα1–3Xylα1–3Glcβ1-O-Ser, whose synthesis is catalyzed by the consecutive action of three glycosyltransferas...

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Hlavní autoři: Takeuchi, Hideyuki, Kantharia, Joshua, Sethi, Maya K., Bakker, Hans, Haltiwanger, Robert S.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2012
Témata:
Glycobiology and Extracellular Matrices
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3464504/
https://ncbi.nlm.nih.gov/pubmed/22872643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.401315
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