piRNAs Can Trigger a Multigenerational Epigenetic Memory in the Germline of C. elegans

Transgenerational effects have wide-ranging implications for human health, biological adaptation, and evolution; however, their mechanisms and biology remain poorly understood. Here, we demonstrate that a germline nuclear small RNA/chromatin pathway can maintain stable inheritance for many generatio...

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Autors principals: Ashe, Alyson, Sapetschnig, Alexandra, Weick, Eva-Maria, Mitchell, Jacinth, Bagijn, Marloes P., Cording, Amy C., Doebley, Anna-Lisa, Goldstein, Leonard D., Lehrbach, Nicolas J., Le Pen, Jérémie, Pintacuda, Greta, Sakaguchi, Aisa, Sarkies, Peter, Ahmed, Shawn, Miska, Eric A.
Format: Artigo
Idioma:Inglês
Publicat: Cell Press 2012
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3464430/
https://ncbi.nlm.nih.gov/pubmed/22738725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2012.06.018
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