Human tumor suppressor EXT gene family members EXTL1 and EXTL3 encode α1,4- N-acetylglucosaminyltransferases that likely are involved in heparan sulfate/ heparin biosynthesis

The tumor suppressors EXT1 and EXT2 are associated with hereditary multiple exostoses and encode bifunctional glycosyltransferases essential for chain polymerization of heparan sulfate (HS) and its analog, heparin (Hep). Three highly homologous EXT-like genes, EXTL1–EXTL3, have been cloned, and EXTL...

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Bibliographische Detailangaben
Hauptverfasser: Kim, Byung-Taek, Kitagawa, Hiroshi, Tamura, Jun-ichi, Saito, Toshiyuki, Kusche-Gullberg, Marion, Lindahl, Ulf, Sugahara, Kazuyuki
Format: Artigo
Sprache:Inglês
Veröffentlicht: The National Academy of Sciences 2001
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC34642/
https://ncbi.nlm.nih.gov/pubmed/11390981
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.131188498
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