Modeling Effects of L-Type Ca(2+) Current and Na(+)-Ca(2+) Exchanger on Ca(2+) Trigger Flux in Rabbit Myocytes with Realistic T-Tubule Geometries

The transverse tubular system of rabbit ventricular myocytes consists of cell membrane invaginations (t-tubules) that are essential for efficient cardiac excitation-contraction coupling. In this study, we investigate how t-tubule micro-anatomy, L-type Ca(2+) channel (LCC) clustering, and allosteric...

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Autors principals: Kekenes-Huskey, Peter M., Cheng, Yuhui, Hake, Johan E., Sachse, Frank B., Bridge, John H., Holst, Michael J., McCammon, J. Andrew, McCulloch, Andrew D., Michailova, Anushka P.
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Research Foundation 2012
Matèries:
Physiology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3463892/
https://ncbi.nlm.nih.gov/pubmed/23060801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2012.00351
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