A20 inhibits LUBAC-mediated NF-κB activation by binding linear polyubiquitin chains via its zinc finger 7

Linear polyubiquitination of proteins has recently been implicated in NF-κB signalling and is mediated by the linear ubiquitin chain assembly complex (LUBAC), consisting of HOIL-1, HOIP and Sharpin. However, the mechanisms that regulate linear ubiquitination are still unknown. Here, we show that A20...

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Detalhes bibliográficos
Main Authors: Verhelst, Kelly, Carpentier, Isabelle, Kreike, Marja, Meloni, Laura, Verstrepen, Lynn, Kensche, Tobias, Dikic, Ivan, Beyaert, Rudi
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3463847/
https://ncbi.nlm.nih.gov/pubmed/23032186
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2012.240
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