The proteasomal de-ubiquitinating enzyme POH1 promotes the double-strand DNA break response

The regulation of Ubiquitin (Ub) conjugates generated by the complex network of proteins that promote the mammalian DNA double-strand break (DSB) response is not fully understood. We show here that the Ub protease POH1/rpn11/PSMD14 resident in the 19S proteasome regulatory particle is required for p...

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Bibliographische Detailangaben
Hauptverfasser: Butler, Laura R, Densham, Ruth M, Jia, Junying, Garvin, Alexander J, Stone, Helen R, Shah, Vandna, Weekes, Daniel, Festy, Frederic, Beesley, James, Morris, Joanna R
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3463844/
https://ncbi.nlm.nih.gov/pubmed/22909820
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2012.232
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