Mechanism of action of dichloro-beta-D-ribofuranosylbenzimidazole: effect on in vitro transcription.

The adenosine analog 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole (DRB) and its mono- and triphosphate derivatives inhibit RNA polymerase II-specific transcription in an extract of whole HeLa cells. The analog does not inhibit RNA polymerase III-specific adenovirus VA RNA transcription in the wh...

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Bibliographic Details
Main Authors: Zandomeni, R, Mittleman, B, Bunick, D, Ackerman, S, Weinmann, R
Format: Artigo
Language:Inglês
Published: 1982
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC346375/
https://ncbi.nlm.nih.gov/pubmed/6954467
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