Zoledronic Acid Inhibits Aromatase Activity and Phosphorylation: Potential Mechanism for Additive Zoledronic Acid and Letrozole Drug Interaction

Zoledronic acid (ZA), a bisphosphonate originally indicated for use in osteoporosis, has been reported to exert a direct effect on breast cancer cells, although the mechanism of this effect is currently unknown. Data from the ABCSG-12 and ZO-FAST clinical trials suggest that treatment with the combi...

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Bibliographic Details
Main Authors: Schech, Amanda J., Nemieboka, Brandon E., Brodie, Angela H.
Format: Artigo
Language:Inglês
Published: 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3463743/
https://ncbi.nlm.nih.gov/pubmed/22659283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jsbmb.2012.05.008
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