Evidence for Radical-Mediated Catalysis by HppE – A Study Using Cyclopropyl and Methylenecyclopropyl Substrate Analogues

(S)-2-Hydroxypropylphosphonic acid epoxidase (HppE) is an unusual mononuclear iron enzyme that catalyzes the oxidative epoxidation of (S)-2-hydroxypropylphosphonic acid ((S)-HPP) in the biosynthesis of the antibiotic fosfomycin. HppE also recognizes (R)-2-hydroxypropylphosphonic acid ((R)-HPP) as a...

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Autores principales: Huang, Hui, Chang, Wei-chen, Pai, Pei-Jing, Romo, Anthony, Mansoorabadi, Steven O., Russell, David H., Liu, Hung-wen
Formato: Artigo
Lenguaje:Inglês
Publicado: 2012
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3463719/
https://ncbi.nlm.nih.gov/pubmed/23006053
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja3078126
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