Phase 2 Trial of Pemetrexed in Children and Adolescents with Refractory Solid Tumors: a Children’s Oncology Group Study

BACKGROUND: Pemetrexed is a multi-targeted antifolate that inhibits key enzymes involved in nucleotide biosynthesis. We performed a phase 2 trial of pemetrexed in children with refractory or recurrent solid tumors, including CNS tumors, to estimate the response rate and further define its toxicity p...

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Hauptverfasser: Warwick, Anne B., Malempati, Suman, Krailo, Mark, Melemed, Allen, Gorlick, Richard, Ames, Matthew M., Safgren, Stephanie L., Adamson, Peter C., Blaney, Susan M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3463652/
https://ncbi.nlm.nih.gov/pubmed/22745043
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pbc.24244
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