Virulence Factors Identified by Cryptococcus neoformans Mutant Screen Differentially Modulate Lung Immune Responses and Brain Dissemination

Deletions of cryptococcal PIK1, RUB1, and ENA1 genes independently rendered defects in yeast survival in human CSF and within macrophages. We evaluated virulence potential of these genes by comparing wild-type Cryptococcus neoformans strain H99 with deletant and complement strains in a BALB/c mouse...

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Bibliographic Details
Main Authors: He, Xiumiao, Lyons, Daniel M., Toffaletti, Dena L., Wang, Fuyuan, Qiu, Yafeng, Davis, Michael J., Meister, Daniel L., Dayrit, Jeremy K., Lee, Anthony, Osterholzer, John J., Perfect, John R., Olszewski, Michal A.
Format: Artigo
Language:Inglês
Published: American Society for Investigative Pathology 2012
Subjects:
Regular Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3463625/
https://ncbi.nlm.nih.gov/pubmed/22846723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2012.06.012
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