Virulence Factors Identified by Cryptococcus neoformans Mutant Screen Differentially Modulate Lung Immune Responses and Brain Dissemination

Deletions of cryptococcal PIK1, RUB1, and ENA1 genes independently rendered defects in yeast survival in human CSF and within macrophages. We evaluated virulence potential of these genes by comparing wild-type Cryptococcus neoformans strain H99 with deletant and complement strains in a BALB/c mouse...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Autori principali: He, Xiumiao, Lyons, Daniel M., Toffaletti, Dena L., Wang, Fuyuan, Qiu, Yafeng, Davis, Michael J., Meister, Daniel L., Dayrit, Jeremy K., Lee, Anthony, Osterholzer, John J., Perfect, John R., Olszewski, Michal A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Investigative Pathology 2012
Soggetti:
Regular Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3463625/
https://ncbi.nlm.nih.gov/pubmed/22846723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2012.06.012
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi