Virulence Factors Identified by Cryptococcus neoformans Mutant Screen Differentially Modulate Lung Immune Responses and Brain Dissemination

Deletions of cryptococcal PIK1, RUB1, and ENA1 genes independently rendered defects in yeast survival in human CSF and within macrophages. We evaluated virulence potential of these genes by comparing wild-type Cryptococcus neoformans strain H99 with deletant and complement strains in a BALB/c mouse...

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Detalhes bibliográficos
Main Authors: He, Xiumiao, Lyons, Daniel M., Toffaletti, Dena L., Wang, Fuyuan, Qiu, Yafeng, Davis, Michael J., Meister, Daniel L., Dayrit, Jeremy K., Lee, Anthony, Osterholzer, John J., Perfect, John R., Olszewski, Michal A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2012
Assuntos:
Regular Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3463625/
https://ncbi.nlm.nih.gov/pubmed/22846723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2012.06.012
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