The MAPK1/3 pathway is essential for the deregulation of autophagy observed in G2019S LRRK2 mutant fibroblasts

The link between the deregulation of autophagy and cell death processes can be essential in the development of several neurodegenerative diseases, such as Parkinson disease (PD). However, the molecular mechanism of deregulation of this degradative process in PD patients is unknown. The leucine-rich...

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Autors principals: Bravo-San Pedro, José M., Gómez-Sánchez, Rubén, Niso-Santano, Mireia, Pizarro-Estrella, Elisa, Aiastui-Pujana, Ana, Gorostidi, Ana, Climent, Vicente, López de Maturana, Rakel, Sanchez-Pernaute, Rosario, López de Munain, Adolfo, Fuentes, José M., González-Polo, Rosa A.
Format: Artigo
Idioma:Inglês
Publicat: Landes Bioscience 2012
Matèries:
Autophagic Punctum
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3463455/
https://ncbi.nlm.nih.gov/pubmed/22914360
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/auto.21270
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