LRRK2 Expression Is Deregulated in Fibroblasts and Neurons from Parkinson Patients with Mutations in PINK1

Mutations in PINK1 (PARK6), a serine/threonine kinase involved in mitochondrial homeostasis, are associated with early onset Parkinson’s disease. Fibroblasts from Parkinson’s disease patients with compound heterozygous mutations in exon 7 (c.1488 + 1G > A; c.1252_1488del) showed no apparent signs...

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Detalhes bibliográficos
Publicado no:Mol Neurobiol
Main Authors: Azkona, Garikoitz, López de Maturana, Rakel, del Rio, Patricia, Sousa, Amaya, Vazquez, Nerea, Zubiarrain, Amaia, Jimenez-Blasco, Daniel, Bolaños, Juan P., Morales, Blas, Auburger, Georg, Arbelo, José Matias, Sánchez-Pernaute, Rosario
Formato: Artigo
Idioma:Inglês
Publicado em: Springer US 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5808058/
https://ncbi.nlm.nih.gov/pubmed/27975167
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12035-016-0303-7
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