The MAPK1/3 pathway is essential for the deregulation of autophagy observed in G2019S LRRK2 mutant fibroblasts

The link between the deregulation of autophagy and cell death processes can be essential in the development of several neurodegenerative diseases, such as Parkinson disease (PD). However, the molecular mechanism of deregulation of this degradative process in PD patients is unknown. The leucine-rich...

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Autori principali: Bravo-San Pedro, José M., Gómez-Sánchez, Rubén, Niso-Santano, Mireia, Pizarro-Estrella, Elisa, Aiastui-Pujana, Ana, Gorostidi, Ana, Climent, Vicente, López de Maturana, Rakel, Sanchez-Pernaute, Rosario, López de Munain, Adolfo, Fuentes, José M., González-Polo, Rosa A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Landes Bioscience 2012
Soggetti:
Autophagic Punctum
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3463455/
https://ncbi.nlm.nih.gov/pubmed/22914360
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/auto.21270
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