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Proteolytic Processing Regulates Toll-like Receptor 3 Stability and Endosomal Localization

Toll-like receptors (TLRs) 3, 7, and 9 are innate immune receptors that recognize nucleic acids from pathogens in endosomes and initiate signaling transductions that lead to cytokine production. Activation of TLR9 for signaling requires proteolytic processing within the ectodomain by endosome-associ...

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Detalhes bibliográficos
Main Authors: Qi, Rongsu, Singh, Divyendu, Kao, C. Cheng
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3463343/
https://ncbi.nlm.nih.gov/pubmed/22865861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.387803
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