Identification of UV-protective Activators of Nuclear Factor Erythroid-derived 2-Related Factor 2 (Nrf2) by Combining a Chemical Library Screen with Computer-based Virtual Screening

Nuclear factor erythroid-derived 2-related factor 2 (Nrf2) is a master regulator of cellular antioxidant defense systems, and activation of this transcription factor is a promising strategy for protection of skin and other organs from environmental insults. To identify efficient Nrf2 activators in k...

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Detalhes bibliográficos
Main Authors: Lieder, Franziska, Reisen, Felix, Geppert, Tim, Sollberger, Gabriel, Beer, Hans-Dietmar, auf dem Keller, Ulrich, Schäfer, Matthias, Detmar, Michael, Schneider, Gisbert, Werner, Sabine
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Gene Regulation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3463337/
https://ncbi.nlm.nih.gov/pubmed/22851183
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.383430
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