Nrf2 establishes a glutathione-mediated gradient of UVB cytoprotection in the epidermis

Ultraviolet (UV) B irradiation can severely damage the skin and even induce tumorigenesis. It exerts its effects by direct DNA modification and by formation of reactive oxygen species (ROS). We developed a strategy to genetically activate target gene expression of the transcription factor NF-E2-rela...

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Autors principals: Schäfer, Matthias, Dütsch, Sabine, auf dem Keller, Ulrich, Navid, Fatemeh, Schwarz, Agatha, Johnson, Delinda A., Johnson, Jeffrey A., Werner, Sabine
Format: Artigo
Idioma:Inglês
Publicat: Cold Spring Harbor Laboratory Press 2010
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2867209/
https://ncbi.nlm.nih.gov/pubmed/20478997
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.568810
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