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Nrf2 establishes a glutathione-mediated gradient of UVB cytoprotection in the epidermis
Ultraviolet (UV) B irradiation can severely damage the skin and even induce tumorigenesis. It exerts its effects by direct DNA modification and by formation of reactive oxygen species (ROS). We developed a strategy to genetically activate target gene expression of the transcription factor NF-E2-rela...
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| Hauptverfasser: | , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Cold Spring Harbor Laboratory Press
2010
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2867209/ https://ncbi.nlm.nih.gov/pubmed/20478997 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.568810 |
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