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Design and Functional Characterization of a Novel, Arrestin-Biased Designer G Protein-Coupled Receptor
Mutational modification of distinct muscarinic receptor subtypes has yielded novel designer G protein-coupled receptors (GPCRs) that are unable to bind acetylcholine (ACh), the endogenous muscarinic receptor ligand, but can be efficiently activated by clozapine-N-oxide (CNO), an otherwise pharmacolo...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The American Society for Pharmacology and Experimental Therapeutics
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3463219/ https://ncbi.nlm.nih.gov/pubmed/22821234 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.112.080358 |
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