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Assaying the Kinase Activity of LRRK2 in vitro
Leucine Rich Repeat Kinase 2 (LRRK2) is a 2527 amino acid member of the ROCO family of proteins, possessing a complex, multidomain structure including a GTPase domain (termed ROC, for Ras of Complex proteins) and a kinase domain(1). The discovery in 2004 of mutations in LRRK2 that cause Parkinson�...
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| Autor principal: | |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
MyJove Corporation
2012
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3462557/ https://ncbi.nlm.nih.gov/pubmed/22301813 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3791/3495 |
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