Characterization of Zebrafish von Willebrand Factor Reveals Conservation of Domain Structure, Multimerization, and Intracellular Storage

von Willebrand disease (VWD) is the most common inherited human bleeding disorder and is caused by quantitative or qualitative defects in von Willebrand factor (VWF). VWF is a secreted glycoprotein that circulates as large multimers. While reduced VWF is associated with bleeding, elevations in overa...

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Detalhes bibliográficos
Main Authors: Ghosh, Arunima, Vo, Andy, Twiss, Beverly K., Kretz, Colin A., Jozwiak, Mary A., Montgomery, Robert R., Shavit, Jordan A.
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3462383/
https://ncbi.nlm.nih.gov/pubmed/23049555
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2012/214209
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