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Genetic alteration of the D2 domain abolishes von Willebrand factor multimerization and trafficking into storage

BACKGROUND: The large von Willebrand factor (VWF) propeptide (VWFpp) plays a critical role in the multimerization and regulated storage of the mature VWF protein. Although our laboratory and others have identified mutations in von Willebrand disease patients that disrupt VWF multimerization, little...

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Bibliografiske detaljer
Main Authors: Haberichter, S.L., Allmann, A.M., Jozwiak, M.A., Montgomery, R.R., Gill, J.C.
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2745278/
https://ncbi.nlm.nih.gov/pubmed/19192112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1538-7836.2009.03290.x
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