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Genetic alteration of the D2 domain abolishes von Willebrand factor multimerization and trafficking into storage
BACKGROUND: The large von Willebrand factor (VWF) propeptide (VWFpp) plays a critical role in the multimerization and regulated storage of the mature VWF protein. Although our laboratory and others have identified mutations in von Willebrand disease patients that disrupt VWF multimerization, little...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2745278/ https://ncbi.nlm.nih.gov/pubmed/19192112 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1538-7836.2009.03290.x |
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