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In silico aided design of a glycan ligand of sialoadhesin for in vivo targeting of macrophages

Cell specific delivery of therapeutic agents using ligand targeting is gaining interest due to the potential for increased efficacy and reduced side effects. The challenge is to develop a suitable ligand of a cell surface receptor that is selectively expressed on the desired cell. Sialoadhesin (Sn/S...

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Hlavní autoři: Nycholat, Corwin M., Rademacher, Christoph, Kawasaki, Norihito, Paulson, James C.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3462166/
https://ncbi.nlm.nih.gov/pubmed/22967315
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja307501e
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