Thermodynamic Investigation of Inhibitor Binding to 1-Deoxy-d-Xylulose-5-Phosphate Reductoisomerase

[Image: see text] Isothermal titration calorimetry (ITC) was used to investigate the binding of six inhibitors to 1-deoxy-d-xylulose-5-phosphate reductoisomerase (DXR), a target for developing novel anti-infectives. The binding of hydroxamate inhibitors to Escherichia coli DXR is Mg(2+)-dependent, h...

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Bibliografiske detaljer
Main Authors: Cai, Guobin, Deng, Lisheng, Fryszczyn, Bartlomiej G., Brown, Nicholas G., Liu, Zhen, Jiang, Hong, Palzkill, Timothy, Song, Yongcheng
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2012
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3462030/
https://ncbi.nlm.nih.gov/pubmed/23050057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml300071w
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