The signaling adapter Gab1 regulates cell polarity by acting as a PAR protein scaffold

Cell polarity plays a key role in development and is disrupted in tumors, yet the molecules and mechanisms that regulate polarity remain poorly defined. We found that the scaffolding adaptor GAB1 interacts with two polarity proteins, PAR1 and PAR3. GAB1 binds PAR1 and enhances its kinase activity. G...

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Bibliografiske detaljer
Main Authors: Yang, Ziqiang, Xue, Bin, Umitsu, Masataka, Ikura, Mitsuhiko, Muthuswamy, Senthil K., Neel, Benjamin G.
Format: Artigo
Sprog:Inglês
Udgivet: 2012
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3462001/
https://ncbi.nlm.nih.gov/pubmed/22883624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2012.06.037
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